Electrophoresis studies of human synovial mucin
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چکیده
منابع مشابه
Electrophoresis studies of human synovial mucin.
A characteristic property of synovial fluids is the formation of a mucin clot when a weak acid is added. The physical character of the clot may be of some aid in the diagnosis of rheumatoid arthritis (Ropes, Bennett, Cobb, Jacox & Jesser, 1957; Ropes & Bauer, 1953). The clot has also been used as a preliminary step in the isolation of hyaluronic acid (Meyer, Smyth & Dawson, 1939) and its hexosa...
متن کاملSynovial Fluid Mucin.
Synovial mucin, the characteristic component of synovial fluid, was first isolated in 1846 by Frerichs (1846), who precipitated it from joint fluid by addition of. acetic acid. Its high viscosity and peculiar chemical composition made it a subject of much interest. Frerichs realized that it was a complex of protein and carbohydrate components, but little -additional information was added until ...
متن کاملStructural studies of sialylated oligosaccharides of human midcycle cervical mucin.
It was previously shown that reductive alkali treatment of purified human cervical mucin releases a heterogeneous population of reduced neutral, sialylated, and sulfated oligosaccharides (Yurewicz, E. C., and Moghissi, K. S. (1981) J. Biol. Chem. 256, 11895-11904). Four major sialylated oligosaccharide fractions were isolated with approximate compositions of Fuc:GlcNac:Gal:NeuAc:N-acetylgalacto...
متن کاملExpression of mucin 3 and mucin 5AC in arthritic synovial tissue.
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterized by hypertrophy of the synovial tissue, leukocyte infiltration, angiogenesis, and ultimately joint destruction. Mucins (MUCs) are a family of heavily glycosylated proteins that protect epithelial membranes and are used as ligands for cell adhesion. MUC gene expression has been found to be altered in many ...
متن کاملA Quantitative Study of Metachromasy in Synovial Fluid and Mucin
SPECTROPHOTOMETRIC MEASUREMENTS ON SYNOVIAL FLUID AND SOLUTIONS OF MUCIN AND HYALURONATE IN THE PRESENCE OF METHYLENE BLUE SHOWED THAT: 1. Dialyzed synovial fluid was not metachromatic. 2. Albumin and gelatin at a concentration of 1 mg. per ml. inhibited the metachromasy of strong chromotropes. 3. Reduction of the protein of synovial fluid by the use of proteolytic enzymes still did not make th...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1959
ISSN: 0306-3283
DOI: 10.1042/bj0710201